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Dr. Cutler's
Discovery was
covered in:

-TIME
12/1/86

NEWSWEEK
1/12/87

Washington Post
11/18/86


Pheromones oil phoremone explains her discovery of human pheromones

Throughout the animal kingdom, Pheromone oil it was well known (by 1979) that females emit sex attractants that cause males (of the same species) to approach. Animal pheromones were so well understood, by the late 70's, that manufacturers were marketing them as pest controls; pheromones were used to lure and divert animals and bugs to traps to prevent crop and flower damage. I was fortunate Pheromone oil to be one of the scientists working on the research that proved the existence of human pheromones for the first time.

Pheromone oil

The discovery of human sex pheromones appeared in front page stories internationally when my colleagues and I succeeded in peer-reviewed acceptance for publication in scientific journals in 1986. We provided the proof that women and men emitted pheromones into the atmosphere and we showed that extracted pheromones could be collected, frozen for over a year, thawed and then applied on the upper lip of recipients to mimic some of the pheromonal Pheromone oil effects found in nature.

The End

News article in The Washington Post , 11/18/86.
Copyright -The Washington Post Newspaper, Washington DC, USA [Excerpted]

PHEROMONES DISCOVERED IN HUMANS

by Boyce Rensberger, Washington Post Staff Writer
'Scientists in Philadelphia have established for the first time that the human body produces pheromones, special aromatic chemical compounds discharged by one individual that affect the sexual physiology of another.

Although animals have long been known to secrete pheromones, which typically function as sex attractants, and although the existence of such chemicals in humans has long been speculated, the new research is the first to establish their existence in humans

******

Although claims of discovering a human pheromone are not new, the older claims have not been based on controlled experiments and most scientists have not found the arguments persuasive. The new findings are to be published next month in Hormones and Behavior, a prestigious, peer-reviewed scientific journal.

"I think we've finally answered the question. Pheromone effects are real in human beings..." said George Preti, who collaborated on the research...with Winnifred B. Cutler. ***Cutler Pheromone oil is an authority on the relationship between sexual behavior and hormones...*** Although the pheromone findings are new and have not previously been reported, the evidence of a link between heterosexual behavior and women's reproductive physiology has been published, with little public notice, in a series of reports over the last eight years in various scientific journals.

"It's remarkable. A very clear pattern has been emerging and it confirms that a woman's optimal reproductive health is a part of a finely tuned system and that a man, on a regular and sustained basis, is an essential part of it," said Cutler, who has led the research effort. "It wasn't clear until our most recent studies how important male essence really is," she said, "but now that we know this, it helps to explain our earlier findings. You might say that exposure to pheromones is the essence of sex."

End of Washington Post article excerpt


Magazine article in Time, 12/1/86.
Copyright Time, Inc., Rockefeller Center, New York, NY 10020-1393 [Excerpted]

Studies find that male pheromones are good for women's health

By John Leo
Reported by Robert Ajemian
Women who work or live together tend to get their menstrual cycles in sync. That curious phenomenon known for years by scientists and many ordinary folk, has long been suspected as an indication that humans, like insects and some mammals, communicate subtly by sexual aromas known as pheromones. Last week Philadelphia researchers weighed in with two reports showing that scents, including underarm odors, do indeed affect menstrual cycles.

The reports came with a kicker: male scents play a role in maintaining the health of women, particularly the health of the female reproductive system. Researchers at the Monell Chemical Senses Center and the University of Pennsylvania School of Medicine have found that women who have sex with men at least once a week are more likely to have normal menstrual cycles, fewer infertility problems and a Pheromone oil milder menopause than celibate women and women who have sex rarely or sporadically. So the researchers were hardly tentative about the meaning of it all. "What we're saying here is that men are really important for women," said Winnifred Cutler, a biologist and specialist in behavioral endocrinology who conducted the study along with Organic Chemist George Preti. "If you look at all the data, the conclusion is compelling. A man or his essence seems essential for an optimally fertile system." Nor did Cutler shrink from the commercial possibilities. "My dream," she said, "is that manufactured male essence, in creams, sprays or perfumes, can dramatically alter the well-being of women."

End of Time article excerpt


News article in USA Today, 11/19/86
Section D: Life
Copyright -USA Today [Excerpted]

The Real Chemical Reaction Between the Sexes

by Kim Painter

    Chemicals in men's bodies can cause their female sex partners to be more fertile, have more regular menstrual cycles and milder menopause, landmark research shows.

    And women who have sex with men at least once a week benefit most from the chemicals, which apparently work through the sense of smell.

    "The exciting part is the effect we have on each other. Men are important to women," says Dr. Winnifred B. Cutler of Philadelphia, whose studies show for the first time that chemicals called pheromones exist in humans.

    Pheromones have long been known to exist in animals, as scents that attract sex partners. Cutler's new studies...show women are affected by pheromones from men and women:

      *Women with unusually long or short menstrual cycles get closer-to-average cycles after regularly inhaling male essence, described as a compound of male sweat, Pheromone oil hormones and natural body odors. "You just walk into a male locker room," Cutler says, "that's the odor."

      *Women exposed to another woman's "female essence" menstruated at the same time after a few months, confirming a long-observed phenomenon that women who live together menstruate at the same time.

    Cutler's other studies show women who have sex with men at least once a week have regular menstrual cycles and fewer fertility and menopause problems, apparently because of exposure to pheromones.

End of Painter's USA TODAY article excerpt




Magazine article in Newsweek, 1/12/87.
Copyright Newsweek Magazine [Excerpted]

The Chemistry Between People: Are Our Bodies Affected by Another Person’s Scent?

By Terence Monmaney with Susan Katz
The air is loaded with secrets, with intimate messages both unseen and unheard. Ready! A female moth announces, and male moths miles away soon receive the invitation and head upwind, eager to mate. A dog goes into heat, and male dogs all over the neighborhood are drawn by a telltale scent to her masters’ door.

***

In creatures as different as bugs and dogs, life-and-death messages are relayed via a specialized chemical known as a pheromone - a substance that works much like a hormone, but is released by one individual and prompts changes in the physiology or behavior of another.

Ever since scientists discovered pheromones 30 years ago, they’ve found such chemical communication in hundreds of species - from moths to mice to monkeys. And man? Do we, the great communicators, also make use of such potent and unambiguous signals? Is there literal truth to the notion that when people get along, it is because of the right "chemistry"?

There have been plenty of claims. A mother's' pheromones, researchers once said, are what attract her infant to her breasts. *** But while the ideas of human pheromones is intriguing, the dozens or so studies that addressed the possibility in the past 10 years were disappointing: no one established beyond a doubt that human pheromones exists.

Now two new studies are stirring up the pheromone debate with the boldest claims yet. Researchers at the University of Pennsylvania and the Monell Chemical Pheromone oil senses Center, a nonprofit research institute in Philadelphia, say that people produce underarm pheromones that can influence menstrual cycles.

The studies, done by chemist George Preti and biologist Winnifred B. Cutler, are not the first of their kind, but they are the first ones rigorous enough to be published in a respected scientific journal, Hormones and Behavior.

In one study the researchers collected underarm secretions from men who wore a pad in each armpit. This "male essence" {pheromone} was then swabbed, three times a week, on the upper lips of seven women whose cycles typically lasted less than 26 days or more than 33. By the third month of such treatment, the average length of the women's cycles began to approach the optimum 29.5 days - the cycle length associated with highest fertility.

Cutler's conclusion: " Male essence" contains at least one pheromone that "helps promote reproductive health".

Female Essence: The experiment was more rigorous than earlier ones for two reasons. It employed a control group - eight women who were swabbed with alcohol showed no effect - and it was performed in "double-blind" fashion: neither the subjects nor the researchers knew whether alcohol or male essence dissolved in alcohol was being applied until after the study.

***

In Cutler and Preti’s second experiment, they studied menstrual synchrony - the phenomenon that women who live in close quarters tend to have cycles that coincide *** This time Cutler and Preti exposed 10 women with normal cycles to female underarm sweat . After three months of the same sweat-on-the-lip treatment, the women's Pheromone oil cycles were starting roughly in Pheromone oil synchrony with those of the women who had donated the sweat. Menstrual synchrony was first documented in 1970 when psychologist Martha McClintock studied women living in a college dormitory.

But this new study is the first to offer solid Pheromone oil evidence that pheromone are what mediate the effect.

"Pheromones are real in human beings., "concludes Preti...

End of Newsweek Excerpt




CNN Online-WebMD News article, 6/25/99
Copyright WebMD [Excerpted]

click here to see it on their site

Pheromones: Potential participants in your sex life

by Deb Levine

In 1986 Dr. Winifred Cutler, a biologist and behavioral endocrinologist, codiscovered pheromones in our underarms. She and her team of researchers found that once any overbearing underarm sweat was removed, what remained were the odorless materials containing the pheromones.

Dr. Cutler's original studies in the '70s showed that women who have regular sex with men have more regular menstrual cycles than women who have sporadic sex. Regular sex delayed the decline of estrogen and made women more fertile. This led the research team to look for what the man was providing in the equation. By 1986 they realized it was pheromones.

 

     

A Secret Sense in the Human Nose: Pheromones and Mammals Just what do the VNOs of rodents—or, perhaps, humans—respond to? Probably pheromones, a kind of chemical signal originally studied in insects. The first pheromone ever identified (in 1956) was a powerful sex attractant for silkworm moths. A team of German researchers worked 20 years to isolate it. After removing certain glands at the tip of the abdomen of 500,000 female moths, they extracted a curious compound. The minutest amount of it made male moths beat their wings madly in a "flutter dance." This clear sign that the males had sensed the attractant enabled the scientists to purify the pheromone. Step by step, they removed extraneous matter and sharply reduced the amount of attractant needed to provoke the flutter dance. When at last they obtained a chemically pure pheromone, they named it "bombykol" for the silkworm moth, "Bombyx mori" from which it was extracted. It signaled, "come to me!" from great distances. "It has been soberly calculated that if a single female moth were to release all the bombykol in her sac in a single spray, all at once, she could theoretically attract a trillion males in the instant," wrote Lewis Thomas in The Lives of a Cell. In dealing with mammals, however, scientists faced an entirely different problem. Compared to insects, whose behavior is stereotyped and highly predictable, mammals are independent, ornery, complex creatures. Their behavior varies greatly, and its meaning is not always clear. What scientists need is "a behavioral assay that is really specific, that leaves no doubt," explains Alan Singer of the Monell Chemical Senses Center. A few years ago, Singer and Foteos Macrides of the Worcester Foundation for Experimental Biology in Massachusetts did find an assay that worked with hamsters—but the experiment would be hard to repeat with larger mammals. It went as follows: First the researchers anesthetized a male golden hamster and placed it in a cage. Then they let a normal male hamster into the same cage. The normal hamster either ignored the anesthetized stranger or bit its ears and dragged it around the cage. Next the researchers repeated the procedure with an anesthetized male hamster on which they had rubbed some vaginal secretions from a female hamster. This time the normal male hamster's reaction was quite different: instead of rejecting the anesthetized male, the hamster tried to mate with it. Eventually Singer isolated the protein that triggered this clear-cut response. "Aphrodisin," as the researchers called it, appears to be a carrier protein for a smaller molecule that is tightly bound to it and may be the real pheromone. The substance seems to work through the VNO, since male hamsters do not respond to it when their VNOs have been removed. Many other substances have powerful effects on lower mammals, but the pheromones involved have not been precisely identified and it is not clear whether they activate the VNO or the main olfactory system, or both. Humans are "the hardest of all" mammals to work with, Singer says. Yet some studies suggest that humans may also respond to some chemical signals from other people. In 1971, Martha McClintock, a researcher who is now at the University of Chicago (she was then at Harvard University), noted that college women who lived in the same dormitory and spent a lot of time together gradually developed closer menstrual cycles. Though the women's cycles were randomly scattered when they arrived, after a while their timing became more synchronized. McClintock is now doing a new study of women's menstrual cycles, based on her findings from an experiment with rats. When she exposed a group of female rats—let's call them the "A" rats—to airborne "chemosignals" taken from various phases of other rats' estrous cycles, she discovered that one set of signals significantly shortened the A rats' cycles, while another set lengthened them. Now she wants to know whether the same is true for humans—whether there are two opposing pheromones that can either delay or advance women's cycles. In this study, she is focusing on the exact time of ovulation rather than on synchrony. The most direct scientific route to understanding pheromones and the VNO may, once again, be through genetics. Working with sensory neurons from the VNOs of rats, Catherine Dulac and Richard Axel found a new family of genes that "are likely to encode mammalian pheromone receptors," they reported in 1995. Axel and Buck's teams also found a similar family in the VNO's of mice. Both groups estimate there must be 50 to 100 distinct genes of this kind in VNO neurons. Since then, Buck's team and that of Catherine Dulac, who is now an HHMI investigator at Harvard, have found a second family of likely pheromone receptors in mammalian VNOs; these, too, are expected to include about 100 genes. "Now we have to match up pheromones and receptors," Buck declares. Once the genes for such receptors are definitively identified, it should be relatively easy to find out whether equivalent genes exist in humans. Scientists could then determine, once and for all, whether such genes are expressed in the human nose. If they are, the receptors may provide a new scientific clue to the compelling mystery of attraction between men and women—some evidence of real, measurable sexual chemistry. — Maya Pines < Previous | Top of page